my last vvvv setup looks like this:

4 video projectors + 1 control monitor (2 triplehead) 6x(1024x768)
4 IDS uEye GigE @ 1024x768 @25 fps (Works with the WDM drivers or Joreg uEye plugin)
1 Wifi IP Camera (WDM) @ 640x480 @30fps
1 USB Webcam
3 filestream (video + audio) @1024x768 @25 fps
1 BassAsio filestream trigged by HF midi pressure sensors
1 BassAsio AudioIn + FFT
1 TimelinerSA with 40 tracks and 120 states
OSC networking over wifi
10 shaders (videoin and filestream)
1 FluidSolver
1 Enttec DMX (artnet)
2 Wiimotes
1 graphic Tablet
1 BCR2000

all this on one shuttle i7/GTX260/2 SSD/xp 32bits
:)